At Aplos Analytics, our goal has always been to make pharmacokinetic analysis faster, more accessible, and more transparent. Over the past year, we have worked closely with customers, trial users, and industry experts to understand how scientists use Aplos NCA in real-world environments and where we could make the biggest impact.
The result is the most significant update to Aplos NCA since its launch.
Coming soon, users will gain access to a completely redesigned platform experience that connects every stage of the workflow, from data preparation and PK analysis to custom calculations, reporting, validation, and archiving.
While the science behind the calculations remains unchanged, the way users interact with and manage their analyses has been fundamentally improved.
The updated platform introduces a new home page that serves as a central hub for all activities. Users can quickly access data files, analyses, reports, validation tools, documentation, support resources, and administrative functions from a single location.
The redesign was driven by a simple principle: scientists should be able to focus on their analysis rather than navigating software.
The new interface provides a clearer workflow, better organization of projects, and improved visibility across every stage of an analysis.
Data preparation is often one of the most time consuming steps in pharmacokinetic analysis.
The new Aplos NCA workflow introduces a dedicated data cleaning environment that allows users to build and reuse processing rules directly within the platform.
Users can:
Every cleaned dataset maintains a parent-child relationship with its source dataset, creating a transparent audit trail of all transformations applied throughout the workflow.
This structure allows users to revisit previous cleaning steps, make adjustments, and generate updated datasets without starting from scratch.
Once a dataset is ready, users can move directly into PK analysis.
The new analysis workflow preserves the familiar flexibility of Aplos NCA while improving usability and transparency. Users can configure studies, select parameters, review source data, and execute analyses through a streamlined interface.
Behind the scenes, Aplos NCA maintains a complete hierarchy of all analysis components, including:
The result is a fully traceable workflow that makes it easier to understand exactly how results were generated.
The updated platform introduces a standardized output structure designed to simplify downstream workflows.
PK Results files now include both rounded values based on significant figures and maximum precision values generated by the calculation engine. This allows scientists to work with publication-ready values while still retaining access to the full computational precision when needed.
Additional enhancements include improved handling of partial AUC calculations, expanded access to terminal slope estimates, and structured individual profile outputs.
For users who want to investigate alternative terminal slope selections, all KEL estimates remain available within the analysis outputs rather than only the selected best fit result.
Many studies require calculations beyond standard PK parameters.
The new custom calculation workflow allows users to generate additional endpoints directly from existing PK results.
Examples include:
Custom calculations become part of the overall analysis hierarchy, maintaining the same traceability and reproducibility as every other workflow stage.
Outputs are standardized, easy to identify, and can be reconfigured or rerun as study requirements evolve.
The platform now provides a more flexible approach to post processing and report generation.
Users can generate:
Reports are built through configurable sections, allowing users to organize outputs in a way that best supports internal reviews, regulatory submissions, or scientific communication.
Because reporting is now integrated directly into the workflow, users can easily generate multiple report versions without recreating analyses.
For users who prefer automation and reproducibility, the platform introduces an Advanced Analysis mode.
Instead of moving through each workflow step individually, users can execute an entire analysis using a predefined JSON configuration that includes:
This approach enables highly efficient execution of repeat analyses while preserving all workflow documentation and outputs.
One of the most important aspects of this update is that it was shaped directly by the scientists who use Aplos NCA.
Feedback from customers and trial users influenced everything from workflow organization and archive management to reporting structures and output formats.
The result is a platform designed not only to perform calculations, but also to support the way scientists actually work.
This update represents a major step forward for Aplos NCA.
By bringing together data preparation, analysis, custom calculations, reporting, and workflow management into a single connected environment, Aplos NCA helps scientists move more efficiently from raw data to final results while maintaining complete traceability throughout the process.
Over the coming weeks, we will continue sharing demonstrations of the new capabilities and workflows before the official release.
Stay tuned for the next generation of Aplos NCA.
Check the full YouTube videos here: https://youtube.com/playlist?list=PLGnYirqcDIjjJnEsHHcGy88RGFs1OHqxv&si=_98DOlXbPuWLYFjc